solid dispersion approach improving dissolution rate of stiripentol: a novel antiepileptic drug
نویسندگان
چکیده
some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic carrier for poorly water soluble drugs in order to improvetheir bioavailability. stp and peg-6000 binary system was obtained by physical mixture,solvent evaporation, co-evaporation and melting methods using different weight ratios.the properties of the prepared binary systems were evaluated using dissolution rate, phasesolubility, fourier-transform infrared (ftir) spectroscopy, differential scanning calorimetry(dsc) and scanning electron microscope (sem) studies. the ftir spectroscopic studiesshowed the stability of stp and absence of stp-peg-6000 interaction. the dsc and semstudies indicated the amorphous state of stp in its binary systems with peg-6000.dissolution profile of stp was significantly improved via complexation with peg-6000 ascompared with the pure drug. the binary system which was prepared using melting methodshowed the highest dissolution rate. the promising results of the prepared binary systems openthe avenue for further oral formulation of stp.
منابع مشابه
Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slow dissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that is structurally unrelated to the currently available antiepileptics. It has poor aqueous solubility and its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) is commonly utilized as a hydroph...
متن کاملStiripentol. A novel antiepileptic drug.
Epilepsy is one of the most widespread pathologies of human brain, affecting approximately 1% of world population. Despite the development of new methods of seizure control, chronic administration of antiepileptic drugs (AEDs) remains the treatment of choice. Nevertheless, pharmacotherapy is not always effective. In the case of single drug treatment, the number of non-responding patients is as ...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۴، شماره ۴، صفحات ۱۰۰۱-۱۰۱۴
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